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Chemical Structure : JW-65
Catalog No.: PC-72922Not For Human Use, Lab Use Only.
JW-65 (JW65) is a selective, potent, CNS-permeable TRPC3 inhibitor improved stability compared to Pyr3.
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JW-65 (JW65) is a selective, potent,CNS-permeable TRPC3 inhibitor improved stability compared to Pyr3.
JW-65 shows similar potency and selectivity on TRPC3 channels, but is metabolically much more stable than its precursor, demonstrated by its much longer half-life (>4 h) in mouse, rat, and human liver microsomes when compared to Pyr3.
JW-65-treated mice showed substantially decreased susceptibility to PTZ-induced seizures in a dose-dependent manner.
| M.Wt | 445.223 | |
| Formula | C18H13Cl2F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marwa M Nagib, et al. Epilepsia. 2022 Feb 18. doi: 10.1111/epi.17190.
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