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Chemical Structure : JW74
CAS No.: 863405-60-1
Catalog No.: PC-45698Not For Human Use, Lab Use Only.
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling with IC50 of 0.79 uM in ST-Luc assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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JW74 is an efficient and specific inhibitor of the canonical Wnt signaling with IC50 of 0.79 uM in ST-Luc assay.
JW74 reduces active β-catenin and downregulates Wnt target genes AXIN2, SP5, and NKD1.
JW74 inhibits tumor growth in mouse xenograft model.
| M.Wt | 456.5196 | |
| Formula | C24H20N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]- |
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1. Waaler J, et al. Cancer Res. 2011 Jan 1;71(1):197-205.
2. Stratford EW, et al. Cancer Med. 2014 Feb;3(1):36-46.
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