JWD-065 | HIPK2 inhibitor | Probechem Biochemicals

Chemical Structure : JWD-065

JWD-065 (JWD 065)

Catalog No.: PC-73292Not For Human Use, Lab Use Only.

JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM.

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Biological Activity

JWD-065 is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 641 nM.

Physicochemical Properties

M.Wt	462.572
Formula	C24H26N6O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propenamide, N-[3-[[4-amino-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-thiazolyl]carbonyl]phenyl]-

References

1. Sebum Lee, et al. Neuron. 2016, 91(1), 41-55.

2. Miduturu CV et al. Chem Biol. 2011;18:868–879.

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JWD-065 (JWD 065)

Biological Activity

Physicochemical Properties

References

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