Chemical Structure : JWG-071
CAS No.: 2250323-50-1
Catalog No.: PC-72141Not For Human Use, Lab Use Only.
JWG-071 is a selective Erk5 inhibitor (IC50<20 nM) with reduced Brd4/BET inhibitory activity.
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JWG-071 is a selective ERK5 inhibitor (IC50<20 nM) with reduced Brd4/BET inhibitory activity.
JWG-071 does not suppress the Brd4 target gene c-Myc, unlike XMD8-85.
JWG-071 inhibits Erk5-dependent c-Myc phosphorylation and degradation, specific Erk5 inhibition drives Dnmt3b expression.
M.Wt | 612.779 | |
Formula | C34H44N8O3 | |
Appearance | Solid | |
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1. Ignazia Tusa, et al. Oncogene. 2018 May;37(19):2601-2614.
2. Charles A C Williams, et al. Cell Rep. 2016 Aug 16;16(7):1820-8.
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