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Chemical Structure : Jun9-62-2R
Catalog No.: PC-72516Not For Human Use, Lab Use Only.
Jun9-62-2R is a potent, selective, covalent SARS-CoV-2 Mpro inhibitor with IC50 of 0.43 uM.
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Jun9-62-2R is a potent, selective, covalent SARS-CoV-2 Mpro inhibitor with IC50 of 0.43 uM.
Jun9-62-2R is highly selective toward Mpro and does not inhibit the host calpain I, cathepsins B, K, L, caspase-3, and trypsin.
Jun9-62-2R inhibited SARS-CoV-2 viral replication with an EC50 of 2.05 μM in Caco2-hACE2 cells.
Jun9-62-2R forms a covalent adduct with the catalytic cysteine Cys145 of SARS-CoV-2 Mpro.
| M.Wt | 518.438 | |
| Formula | C29H25Cl2N3O2 | |
| Appearance | Solid | |
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1. Chunlong Ma, et al. J Am Chem Soc. 2021 Dec 15;143(49):20697-20709.
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