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K-Ras G12C-IN-12

Chemical Structure : K-Ras G12C-IN-12

CAS No.: 1469337-95-8

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K-Ras G12C-IN-12

Catalog No.: PC-45536Not For Human Use, Lab Use Only.

An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells; relys on the mutant cysteine for binding and therefore do not affect the wild-type K-Ras.

Physicochemical Properties

M.Wt 449.6713
Formula C15H17ClIN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 48 mg/mL
Chemical Name/SMILES

2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-

References

1. Ostrem JM, et al. Nature. 2013 Nov 28;503(7477):548-51.

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