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Chemical Structure : K6PC-5
Catalog No.: PC-49431Not For Human Use, Lab Use Only.
K6PC-5 is a synthetic ceramide derivative, selective and direct sphingosine kinase 1 (SphK1) activator.
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K6PC-5 is a synthetic ceramide derivative, selective and direct sphingosine kinase 1 (SphK1) activator.
K6PC-5 ameliorates intestinal homeostasis in an animal model of Huntington's disease.
K6PC-5 increases intracellular calcium levels and promote epidermal keratinocyte differentiation, stimulates the phosphorylation of p42/44 extracellular signal-regulated kinase and c-Jun N-terminal kinase.
K6PC-5 inhibits OGD/reoxygenation-induced myocardial cell death probably through activating SphK1.
K6PC-5 markedly reduces the EBOV titer in infected cells and the de novo production of viral proteins in endothelial cells.
| M.Wt | 343.50 | |
| Formula | C19H37NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kwon YB, et al. J Lipid Res. 2007 Sep;48(9):1936-43.
2. Park HY, et al. Exp Dermatol. 2008 Oct;17(10):829-36.
3. Hong JH, et al. J Invest Dermatol. 2008 Sep;128(9):2166-78.
4. Imre G, et al. iScience. 2021 Mar 5;24(4):102266.
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