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Chemical Structure : KB-141
Catalog No.: PC-35610Not For Human Use, Lab Use Only.
KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα.
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KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα; selectively reduces plasma cholesterol levels, also increases whole body oxygen consumption (MVO2) in both mice and rats.
| M.Wt | 355.21 | |
| Formula | C17H16Cl2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Grover GJ, et al. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72.
2. Johansson L, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302.
3. Grover GJ, et al. Cardiovasc Drug Rev. 2005 Summer;23(2):133-48. Review.
4. Ye L, et al. J Med Chem. 2003 Apr 24;46(9):1580-8.
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