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Chemical Structure : KB-R7943
CAS No.: 182004-65-5
Catalog No.: PC-73274Not For Human Use, Lab Use Only.
KB-R7943 (No.7943) is a selective inhibitor of Na+/Ca2+ exchanger (NCX), 3-fold more inhibitory to NCX3 than to NCX1 or NCX2.
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KB-R7943 (No.7943) is a selective inhibitor of Na+/Ca2+ exchanger (NCX), 3-fold more inhibitory to NCX3 than to NCX1 or NCX2.
KB-R7943 inhibits Na+i-dependent 45Ca2+ uptake and Na+i-dependent [Ca2+]i increase in cardiomyocytes, smooth muscle cells, and NCX1-transfected fibroblasts with IC50 of 1.2-2.4 uM.
KB-R7943 is much less potent in inhibiting Na+o-dependent 45Ca2+ efflux and Na+o-induced [Ca2+]i decline (IC50>30 uM).
KB-R7943 inhibited Na+i-dependent 45Ca2+ uptake and Na+o-dependent 45Ca2+ efflux in n cardiac sarcolemmal preparations with IC50 of 5.4-13 uM.
KB-R7943 markedly inhibited Ca2+ overloading into cardiomyocytes under the Ca2+ paradox conditions.
| M.Wt | 427.490 | |
| Formula | C17H21N3O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate |
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1. Iwamoto T, et al. J Biol Chem. 1996 Sep 13;271(37):22391-7.
2. Watano T, et al. Br J Pharmacol. 1996 Oct;119(3):555-63.
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