KBD3536 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : KBD3536

KBD3536 (KBD-3536)

Catalog No.: PC-27383Not For Human Use, Lab Use Only.

KBD3536 is a potent small-molecule NLRP3 inhibitor with IC50 of 27.7 nM in the THP-1 pyroptosis assays, IC50 of 19.5 nM for inhibition of IL-1β secretion in LPS- and ATP-stimulated PBMCs.

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Biological Activity

KBD3536 is a potent small-molecule NLRP3 inhibitor with IC50 of 27.7 nM in the THP-1 pyroptosis assays, IC50 of 19.5 nM for inhibition of IL-1β secretion in LPS- and ATP-stimulated PBMCs.

Physicochemical Properties

M.Wt	417.52
Formula	C21H27N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N'-((3-((R)-1-cyclopropylethyl)bicyclo[4.2.0]octa-1(6),2,4-trien-2-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonimidamide

References

1. Chu, H. et al. Eur. J. Med. Chem. 2026, 301, 118227.

2. Qian X, et al. Pharmaceuticals (Basel). 2026 Jul 14;19(7):1083.

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KBD3536 (KBD-3536)

Biological Activity

Physicochemical Properties

References

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