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Chemical Structure : KCN1
Catalog No.: PC-35912Not For Human Use, Lab Use Only.
KCN1 (HIF inhibitor KCN1) is a small molecule inhibitor of the HIF-1 pathway, antagonizes HIF transcription in bioassay, blocks the p300/HIF-1α interaction, and exert potent anticancer activity in vitro and in vivo.
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KCN1 (HIF inhibitor KCN1) is a small molecule inhibitor of the HIF-1 pathway, antagonizes HIF transcription in bioassay, blocks the p300/HIF-1α interaction, and exert potent anticancer activity in vitro and in vivo; specifically inhibits HIF reporter gene activity in several glioma cell lines at the nanomolar leve, also downregulates transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE)-dependent manner; inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.
| M.Wt | 465.56 | |
| Formula | C26H27NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yin S, et al. Clin Cancer Res. 2012 Dec 15;18(24):6623-33.
2. Shi Q, et al. ACS Med Chem Lett. 2012 Jun 21;3(8):620-5.
3. Wang W, et al. PLoS One. 2012;7(9):e44883.
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