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Chemical Structure : KD5170
CAS No.: 940943-37-3
Catalog No.: PC-21042Not For Human Use, Lab Use Only.
KD5170 (KD-5170) is a potent mercaptoketone-based Class I and II-histone deacetylase (HDAC) inhibitor with IC50 of 45 nM in HeLa cell-based histone H3 hyperacetylation assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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KD5170 (KD-5170) is a potent mercaptoketone-based Class I and II-histone deacetylase (HDAC) inhibitor with IC50 of 45 nM in HeLa cell-based histone H3 hyperacetylation assay.
KD5170 displays cytotoxic activities of KD5170 against cell lines from the NCI-60 panel with micromolar to submicromolar potency.
KD5170 (30 mg/kg oral dose) increases tumor H3 hyperacetylation in vivo.
KD5170 (42 and 84 mg/kg) exhibits significant tumor growth inhibition in HCT-116 tumor bearing nude mice.
| M.Wt | 451.56 | |
| Formula | C20H25N3O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
S-(2-(6-((4-(3-(dimethylamino)propoxy)phenyl)sulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate |
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1. Payne JE, et al. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6093-6.
2. Feng R,et al. Mol Cancer Ther. 2008 Jun;7(6):1494-505.
3. Hassig CA, et al.Mol Cancer Ther. 2008 May;7(5):1054-65.
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