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Chemical Structure : KDM5-IN-48
CAS No.: 1628210-26-3
Catalog No.: PC-42149Not For Human Use, Lab Use Only.
KDM5-IN-48 is a potent, selective and orally bioavailable KDM5 inhibitor with biochemical IC50 of 15.1, 4.7 and 65.5 nM for KDM5A, KDM5B and KDM5C, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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KDM5-IN-48 is a potent, selective and orally bioavailable KDM5 inhibitor with biochemical IC50 of 15.1, 4.7 and 65.5 nM for KDM5A, KDM5B and KDM5C, respectively.
KDM5-IN-48 displays significantly less potent against other KDM enzymes (KDM4C IC50=1.9 uM).
KDM5-IN-48 increases H3K4Me3 level in PC9 cells with EC50 of 0.34 uM.
KDM5-IN-48 possesses suitable physiochemical properties and displays excellent PK profile in mice.
| M.Wt | 324.3803 | |
| Formula | C17H20N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5-[1-(1,1-dimethylethyl)-1H-pyrazol-4-yl]-4,7-dihydro-6-(1-methylethyl)-7-oxo- |
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1. Liang J, et al. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41.
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