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Chemical Structure : KDM5A-IN-50
Catalog No.: PC-62835Not For Human Use, Lab Use Only.
KDM5A-IN-50 is a potent, selective, and orally bioavailable pan KDM5 enzyme inhibitor with biochemical IC50 of 45/56/55 nM for KDM5A/KDM5B/KDM5C respectively.
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KDM5A-IN-50 is a potent, selective, and orally bioavailable pan KDM5 enzyme inhibitor with biochemical IC50 of 45/56/55 nM for KDM5A/KDM5B/KDM5C respectively; significantly less potent against other KDM enzymes (1A, 2B, 3B, 4C, 6A, 7B); inhibits H3K4Me3 level in PC9 cells with EC50 of 960 nM; has promising in vivo PK profiles.
| M.Wt | 290.367 | |
| Formula | C15H22N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liang J, et al. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2974-2981.
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