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Chemical Structure : KDU731
Catalog No.: PC-62150Not For Human Use, Lab Use Only.
KDU731 is a potent, selective parasite Cryptosporidium lipid kinase PI4K (phosphatidylinositol-4-OH kinase) inhibitor with IC50 of 25 nM, displays >50-fold selectivity window against the human PI4K IIIβ homologue.
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KDU731 is a potent, selective parasite Cryptosporidium lipid kinase PI4K (phosphatidylinositol-4-OH kinase) inhibitor with IC50 of 25 nM, displays >50-fold selectivity window against the human PI4K IIIβ homologue.
KDU731 shows HepG2 CC50 of 15.6 uM and C. parvum CPE EC50 of 0.1 uM.
KDU731 demonstrates a potent reduction in intestinal infection of immunocompromised mice after oral treatment, also leads to rapid resolution of diarrhoea and dehydration in neonatal calves, a clinical model of cryptosporidiosis that closely resembles human infection.
| M.Wt | 396.41 | |
| Formula | C22H16N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Manjunatha UH, et al. Nature. 2017 Jun 15;546(7658):376-380.
2. Ward HD. Trends Parasitol. 2017 Sep;33(9):662-664.
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