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Chemical Structure : KF26777
Catalog No.: PC-20639Not For Human Use, Lab Use Only.
KF-26777 (KF26777) is a potent and selective adenosine A3 receptor antagonist with Ki of 0.2 nM (human A3 receptor).
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KF-26777 (KF26777) is a potent and selective adenosine A3 receptor antagonist with Ki of 0.2 nM (human A3 receptor).
KF-26777 displays 9000-, 2350- and 3100-fold selectivity vs. human adenosine A(1), A(2A) and A(2B) receptors, respectively.
KF26777 inhibits the binding of [35S]GTPgammaS stimulated by 1 microM 2-Cl-IB-MECA in competitive binding assays (IC50=250 nM).
KF26777 antagonizes [Ca(2+)](i) mobilization induced by Cl-IB-MECA with K(B) value of 0.42 nM.
| M.Wt | 374.24 | |
| Formula | C16H16BrN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Saki M, et al. Eur J Pharmacol. 2002 May 31;444(3):133-41.
2. Yamano K, et al. Biochem Pharmacol. 2005 Nov 15;70(10):1487-96.
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