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Chemical Structure : KGA-2727
CAS No.: 666842-36-0
Catalog No.: PC-63375Not For Human Use, Lab Use Only.
KGA-2727 is a potent, selective SGLT1 inhibitor with Ki of 97.4 nM, >100-fold selectivity over SGLT2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote | ||
| 250 mg | Get quote | ||
| 1 g | Get quote |
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KGA-2727 is a potent, selective SGLT1 inhibitor with Ki of 97.4 nM, >100-fold selectivity over SGLT2.
KGA-2727 attenuates the elevation of plasma glucose after glucose loading in streptozotocin-induced diabetic rats, preserves glucose-stimulated insulin secretion and reduces urinary glucose excretion with improved morphological changes of pancreatic islets and renal distal tubules in ZDF rats.
| M.Wt | 536.626 | |
| Formula | C26H40N4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-((3-(4-((5-isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)propanamide |
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1. Shibazaki T, et al. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96.
2. Dobbins RL, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1;308(11):G946-54.
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