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Chemical Structure : KH-259
Catalog No.: PC-49072Not For Human Use, Lab Use Only.
KH-259 is a potent, isozyme-selective and CNS-penetrant HDAC6 inhibitor with IC50 of 260 nM, shows weak activity against HDAC1 and HDAC4 (IC50>6 uM).
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KH-259 is a potent, isozyme-selective and CNS-penetrant HDAC6 inhibitor with IC50 of 260 nM, shows weak activity against HDAC1 and HDAC4 (IC50>6 uM).
KH-259 (10 mg/kg, i.p.) demonstrated antidepressant activity and increased acetylated α-tubulin in the brain without promoting acetylated histone H3K9.
| M.Wt | 339.439 | |
| Formula | C20H25N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kosuke Hashimoto, et al. ACS Med. Chem. Lett. 2022
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