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Chemical Structure : KH-CB19
Catalog No.: PC-43237Not For Human Use, Lab Use Only.
KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform.
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KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform.
KH-CB19 effectively suppresses phosphorylation of SR (serine/arginine) proteins SRp75 and SRp55 in cells.
KH-CB19 significantly reduces the basal expression of flTF as well as asHTF, also lowers TNF-α-induced expression of both TF mRNA splice variants to baseline in HMEC-1 cells.
| M.Wt | 338.1886 | |
| Formula | C15H13Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fedorov O, et al. Chem Biol. 2011 Jan 28;18(1):67-76.
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