Chemical Structure : KKL-1005
CAS No.:
489397-99-1
KKL-1005
(KKL1005)
Catalog No.: PC-25448Not For Human Use, Lab Use Only.
KKL-1005 is an anti-tubercular triazole-based molecule, binds to ribosomal protein bL12 (MST Kd=8 uM, purified E. coli bL12) and specifically inhibits the trans-translation ribosome rescue pathway, inhibits trans-translation in E. coli cells with IC50 of <1.5 uM in E. coli expressing mCherry-trpAt.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KKL-1005 is an anti-tubercular triazole-based molecule, binds to ribosomal protein bL12 (MST Kd=8 uM, purified E. coli bL12) and specifically inhibits the trans-translation ribosome rescue pathway, inhibits trans-translation in E. coli cells with IC50 of <1.5 uM in E. coli expressing mCherry-trpAt.
KKL-1005 inhibits M. tuberculosis trans-translation in in vitro with IC50 of 37 uM.
KKL-1005 inhibits growth of strain H37Rv by 95.5% when present at 10 µM (3.7 µg/mL).
KKL-1005 inhibits growth of the attenuated M. tuberculosis strain H37Rv ΔRD1 ΔpanCD with MIC of 4.7 ug/mL.
KKL-1005 binds the N-terminal domain of ribosomal protein bL12, binds with purified M. tuberculosis bL12 with MST Kd of 4 uM.
Overexpression of bL12 suppresses growth inhibition by KKL-1005.
Physicochemical Properties
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M.Wt
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373.37
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Formula
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C20H15N5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(5-benzamido-2-phenyl-1,2,4-triazol-3-yl)furan-2-carboxamide
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References
1. Varshney A, et al. J Bacteriol. 2025 Sep 3:e0023625.
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