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Chemical Structure : KKL-55
Catalog No.: PC-21141Not For Human Use, Lab Use Only.
KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.
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KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.
KKL-55 specifically inhibits EF-Tu activity in trans-translation without affecting its activity in normal translation.
KKL-55 binds domain 3 of EF-Tu, alters EF-Tu binding to tmRNA.
| M.Wt | 265.70 | |
| Formula | C11H12ClN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Neeraja Marathe, et al. mBio. 2023 Sep 8;e0146123. doi: 10.1128/mbio.01461-23.
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