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Chemical Structure : KNI-1657
Catalog No.: PC-35156Not For Human Use, Lab Use Only.
KNI-1657 (KNI1657) is a highly potent HIV-1 protease inhibitor (97% inhibition at 1 nM) with high sensitivity against lopinavir/ritonavir- or darunavir-resistant strains.
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KNI-1657 (KNI1657) is a highly potent HIV-1 protease inhibitor (97% inhibition at 1 nM) with high sensitivity against lopinavir/ritonavir- or darunavir-resistant strains.
KNI-1657 inhibits wild-type HIV-1 (pNL4-3) and LPV-resistant strain A17 with IC50 of <3 and 25 nM, respectively.
| M.Wt | 756.915 | |
| Formula | C41H48N4O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hidaka K, et al. J Med Chem. 2018 May 31. doi: 10.1021/acs.jmedchem.7b01709.
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