Chemical Structure : KP372-1
CAS No.:
1374996-60-7
KP372-1
Catalog No.: PC-25404Not For Human Use, Lab Use Only.
KP372-1 is a small molecule Akt inhibitor, blocks signalling through the PI3K pathway and inhibits cell proliferation while inducing apoptosis of thyroid cancer cells.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KP372-1 is a small molecule Akt inhibitor, blocks signalling through the PI3K pathway and inhibits cell proliferation while inducing apoptosis of thyroid cancer cells.
KP372-1 blocks signalling downstream of Akt in thyroid tumour cells, leading to inhibition of cell proliferation and increased apoptosis.
KP372-1 blocked the activation of Akt, inhibited head and neck cancer cell proliferation, and induced apoptosis and anoikis in several HNSCC cell lines.
KP372-1 decreased the phosphorylation of the S6 ribosomal (Ser240/244) protein, which is a downstream target of Akt.
KP372-1 directly inhibited the kinase activity of AKT, PDK1, and FLT3 in a concentration-dependent manner.
KP372-1 markedly decreased the colony-forming ability of primary AML samples (IC50<200 nM) with minimal cytotoxic effects on normal progenitor cells.
Physicochemical Properties
|
M.Wt
|
448.36
|
|
Formula
|
C20H8N12O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one, compd. with 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one (1:1)
|
References
1. Mandal M, et al. Br J Cancer. 2005 May 23;92(10):1899-905.
2. Mandal M, et al. Oral Oncol. 2006 Apr;42(4):430-9.
3. Zeng Z, et al. Cancer Res. 2006 Apr 1;66(7):3737-46.
Contact Us
sales@probechem.com
