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Chemical Structure : KR-62436
Catalog No.: PC-35918Not For Human Use, Lab Use Only.
KR-62436 (KR62436) is a potent, selective DPP4 inhibitor with IC50 of 0.78, 0.49, 0.14 uM for rat plasma, porcine kidney, human DPP4 (Caco-2), respectively.
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KR-62436 (KR62436) is a potent, selective DPP4 inhibitor with IC50 of 0.78, 0.49, 0.14 uM for rat plasma, porcine kidney, human DPP4 (Caco-2), respectively.
KR-62436 completely inhibits DPP-IV-mediated degradation of GLP-1 in vitro at 10 uM, exhibits selectivity against several proteases including proline-specific protease.
KR-62436 promotes primary tumor growth and lung metastasis in a 4T1 tumor allograft mouse model, also shows anti-hyperglycemic activity in vivo.
| M.Wt | 297.322 | |
| Formula | C14H15N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kim KR, et al. Eur J Pharmacol. 2005 Jul 25;518(1):63-70.
2. Yang F, et al. Cancer Res. 2018 Dec 24. pii: canres.0620.2018. doi: 10.1158/0008-5472.CAN-18-0620.
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