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Chemical Structure : KRA-533
CAS No.: 10161-87-2
Catalog No.: PC-72963Not For Human Use, Lab Use Only.
KRA-533 (NSC112533, KRA533) is a small molecule KRAS agonist that binds the GTP/GDP-binding pocket of KRAS.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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KRA-533 (NSC112533, KRA533) is a small molecule KRAS agonist that binds the GTP/GDP-binding pocket of KRAS.
KRA-533 activates KRAS in association with growth inhibition of NSCLC cells, directly binds and activates WT and mutant KRAS (G12C, G12D and G13D mutant) in an in vitro cell-free system.
KRA-533 activated exogenous WT and S17A but not K117A KRAS mutant in A549 cells, suggest that the Lys117 hydrogen-bond site is required for KRA-533 to bind or activate KRAS.
KRA-533 induces KRAS activation leading to apoptotic and autophagic cell death in human lung cancer cells.
KRA-533 suppresses mutant KRAS lung cancer in xenograft models.
| M.Wt | 314.179 | |
| Formula | C13H16BrNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(4-(2-bromoacetamido)butyl)benzoic acid |
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1. Ke Xu, et al. Mol Cancer. 2019; 18: 85.
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