KRAS-Q61X inhibitor compound 1

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Chemical Structure : KRAS-Q61X inhibitor compound 1

Catalog No.: PC-27627Not For Human Use, Lab Use Only.

KRAS-Q61X inhibitor compound 1 is a specific small molecule ligand of KRAS-Q61X (X = H, L, K, R), selectively activates GTP hydrolysis of KRAS-Q61X mutants.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KRAS-Q61X inhibitor compound 1 is a specific small molecule ligand of KRAS-Q61X (X = H, L, K, R), selectively activates GTP hydrolysis of KRAS-Q61X mutants.
KRAS-Q61X inhibitor compound 1 does not rescue the hydrolysis of HRAS-Q61R or NRAS-Q61R.
KRAS-Q61X inhibitor compound 1 does not directly engage HRAS and NRAS.

Physicochemical Properties

M.Wt	680.74
Formula	C37H35F3N8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(8-((1H-imidazol-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol

References

1. Ye-Cheng Wang, et al. Nat Chem Biol. 2026 Aug 12. doi: 10.1038/s41589-026-02291-1.

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