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Chemical Structure : KRIBB11
CAS No.: 342639-96-7
Catalog No.: PC-42278Not For Human Use, Lab Use Only.
KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.
KRIBB11 inhibits HSF1 downstream target proteins HSP70 and HSP72 synthesis, induces growth arrest and apoptosis in HCT-116 cells, inhibits HSF1-dependent recruitment of p-TEFb to the hsp70 promoter.
KRIBB11 inhibits tumor growth without body weight loss in mice model.
| M.Wt | 284.27338 | |
| Formula | C13H12N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 27 mg/mL |
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| Chemical Name/SMILES |
2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro- |
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1. Yoon YJ, et al. J Biol Chem. 2011 Jan 21;286(3):1737-47.
2. Kang MJ, et al. Biochem Biophys Res Commun. 2017 Oct 21;492(3):304-309.
3. Carpenter RL, et al. Oncotarget. 2017 May 22;8(43):73947-73963.
4. Samarasinghe B, et al. Biochem Pharmacol. 2014 Feb 1;87(3):445-55.
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