Chemical Structure : KS-40070
CAS No.:
2674133-15-2
KS-40070
(KS40070)
Catalog No.: PC-25352Not For Human Use, Lab Use Only.
KS-40070 is a potent, selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with IC50 of 18 nM, with no inhibition on human DYRK2 (IC50>10 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KS-40070 is a potent, selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with IC50 of 18 nM, with no inhibition on human DYRK2 (IC50>10 uM).
KS-40070 (10 uM) exhibits anti-adipogenesis effect in 3T3-L1 cells and ADMSCs, effectively inhibits lipid droplet accumulation.
KS-40070 (5 uM) reduces the expression of DYRK1B and other adipogenesis transcription factors, such as PPARγ and C/EBPα, in a dose-dependent manner and adipocyte-specific markers are also effectively decreased.
KS-40070 inhibits the nuclear-cytoplasmic translocation of FOXO1A through the inactivation of Akt.
KS-40070 suppressed body weight gain, food consumption, serum lipid levels, and adipose tissue mass in DIO mice.
Physicochemical Properties
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M.Wt
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358.40
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Formula
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C21H18N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(3-(4-methoxyphenyl)-1H-pyrazolo [3,4-b]pyridin-5-yl) phenyl)acetamide
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References
1. Areum Park, et al. Bioorg Med Chem Lett. 2021 Sep 1:47:128226.
2. Kang S, et al. Front Pharmacol. 2025 Jul 29;16:1645033.
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