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Chemical Structure : KS0365
Catalog No.: PC-49275Not For Human Use, Lab Use Only.
KS0365 (KS 0365) is a potent and selective activator of transient receptor potential vanilloid 3 (TRPV3) channel with EC50 of 5.08 uM.
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KS0365 (KS 0365) is a potent and selective activator of transient receptor potential vanilloid 3 (TRPV3) channel with EC50 of 5.08 uM.
KS0365 activated recombinant and native mouse TRPV3 more potently and with a higher efficacy compared to 2-APB.
KS0365 did not activate TRPV1, TRPV2 or TRPV4 channels. KS0365 triggered increases in [Ca2+ ]i, accelerated the EGF-induced keratinocyte migration in vitro.
KS0365 induced strong Ca2+ responses in migrating front cells and in leading edges of keratinocytes.
| M.Wt | 250.766 | |
| Formula | C15H19ClO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marion Maier, et al. Br J Pharmacol. 2022 Aug 2. doi: 10.1111/bph.15937.
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