Catalog No.: PC-72658Not For Human Use, Lab Use Only.
KU-177 (KU177) is a selective small molecule inhibitor of Hsp90 cochaperone AHA1 (activator of Hsp90 ATPase homolog 1, Activator of HSP90 ATPase Activity 1), inhibits interaction between HSP90 and AHA1.
KU-177 (KU177) is a selective small molecule inhibitor of Hsp90 cochaperone AHA1 (activator of Hsp90 ATPase homolog 1, Activator of HSP90 ATPase Activity 1), inhibits interaction between HSP90 and AHA1.
KU-177 inhibits Hsp90-mediated luciferase refolding activity in PC3-MM2 cell with IC50 of 2 uM.
KU-177 inhibits Aha1 enhancement of Hsp90-mediated tau aggregation, increased soluble, phosphorylated tau in cultured cells.
AHSA1-K137 is identified as the site-specific targeting of KU-177 and Bufalin.
KU-177 decreases MM cell proliferation and proteasome inhibitor (PI) resistance induced by AHSA1/HSP90 in vitro (H929 cell IC50=25.8 uM).
KU-177 (1mg/kg, twice per week) extends the survival of 5TMM3VT MM mice when combined with Bortezomib (BTZ) (1mg/kg, twice per week).
