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Chemical Structure : KU-32
Catalog No.: PC-60660Not For Human Use, Lab Use Only.
KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70.
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KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70.
KU-32 protects against neuronal death induced by amyloid β-peptide with minimally cytotoxic to primary cortical neurons.
KU-32 significantly increases the expression of Hsp70 in MCF7 cells at 10 nM, decreases neurodegeneration of non-myelinated or myelinated sensory neurons in vitro and attenuates the pathophysiological progression of DPN in mice.
| M.Wt | 407.419 | |
| Formula | C20H25NO8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ma J, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):281-92.
2. Urban MJ, et al. ASN Neuro. 2010 Aug 11;2(4):e00040.
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