Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : KUNB 31
Catalog No.: PC-62516Not For Human Use, Lab Use Only.
KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94; exhibits anti-proliferative activity against NCI H23, UC3, and HT-29 cancer cell lines with IC50 of 6.74 µM, 3.01 µM, and 3.72 µM, respectively; specificly induces the degradation of Hsp90β-dependent client proteins (EGFR, HER2, CDK4, CDK6, CXCR4 etc.) in cells.
| M.Wt | 322.364 | |
| Formula | C19H18N2O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Khandelwal A, et al. Nat Commun. 2018 Jan 30;9(1):425.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
