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Chemical Structure : KW-2449
CAS No.: 1000669-72-6
Catalog No.: PC-42536Not For Human Use, Lab Use Only.
KW-2449 is a multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $68 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | Get quote |
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KW-2449 is a multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively.
KW-2449 has little effect on PDGFRβ, IGF-1R, EGFR, and various serine/threonine kinases at 1 uM.
KW-2449 exhibits potent growth inhibitory effects on leukemia cells with FLT3 mutations, resulting in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis; orally active.
| M.Wt | 332.399 | |
| Formula | C20H20N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl- |
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1. Shiotsu Y, et al. Blood. 2009 Aug 20;114(8):1607-17.
2. Nguyen T, et al. Clin Cancer Res. 2011 May 15;17(10):3219-32.
3. Pratz KW, et al. Blood. 2009 Apr 23;113(17):3938-46.
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