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KWAR23

Chemical Structure : KWAR23

CAS No.:

KWAR23 (Anti-human SIRPα mAb, human IgG1-Kappa)

Catalog No.: PC-Ab1111Not For Human Use, Lab Use Only.

KWAR23 is a monoclonal anti-human SIRPα antibody that binds to human SIRPα with high affinity, blocks the interaction of CD47 on one cell with SIRPα on a phagocytic cell. KWAR23 induces human macrophage-dependent phagocytosis in human tumor-derived cell lines, restores chemokine secretion in human macrophages in vitro, greatly augments myeloid cell-dependent killing of a collec-tion of hematopoietic and nonhematopoietic human tumor-derived cell lines..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KWAR23 is a monoclonal anti-human SIRPα antibody that binds to human SIRPα with high affinity, blocks the interaction of CD47 on one cell with SIRPα on a phagocytic cell. KWAR23 induces human macrophage-dependent phagocytosis in human tumor-derived cell lines, restores chemokine secretion in human macrophages in vitro, greatly augments myeloid cell-dependent killing of a collec-tion of hematopoietic and nonhematopoietic human tumor-derived cell lines.

Physicochemical Properties

M.Wt
Formula Human IgG1-Kappa
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

References

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