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KYT-1

Chemical Structure : KYT-1

CAS No.: 241825-16-1

KYT-1 (Carbobenzoxy-Lys-Arg-CO-Lys-N-(CH2)2)

Catalog No.: PC-72420Not For Human Use, Lab Use Only.

KYT-1 is a potent, selective inhibitor of P. gingivalis virulence factor Arg-gingipain (Rgp) with Ki 40 nM (RgpA/B).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KYT-1 is a potent, selective inhibitor of P. gingivalis virulence factor Arg-gingipain (Rgp) with Ki 40 nM (RgpA/B).
KYT-1 showed significant inhibitory effects on SMC proliferation stimulated by Porphyromonas gingivalis.

Physicochemical Properties

M.Wt 619.768
Formula C29H49N9O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
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Solubility

Chemical Name/SMILES

References

1. Kadowaki T, et al. Mol Pharmacol. 2004 Dec;66(6):1599-606.

2. Hosn KN, et al. Clin Exp Dent Res. 2015 Oct 27;1(1):18-25.

3. Inaba H, et al. J Periodontol. 2011 Nov;82(11):1616-22.

4. Cao C, et al. Int J Clin Exp Med. 2015 Oct 15;8(10):18327-34.

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