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Chemical Structure : KYT-36
Catalog No.: PC-72419Not For Human Use, Lab Use Only.
KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.
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KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.
KYT-36 consists of benzyloxycarbonyl (BOC), L-glutaminyl (GLN), methylphenylamino (MPA), L-lysinyl (LYS), and benzylcarbamoyl (BCA) moieties.
KYT-36 strongly inhibited degradation of host proteins in culture supernatants and abolished thriving of P. gingivalis in cell cultures and in periodontal pockets in vivo.
KYT-36 prevented Kgp-triggered vascular permeability in guinea pigs, i.e. demonstrating its efficacy against bacterial virulence in vivo, with no toxicity effects.
| M.Wt | 630.746 | |
| Formula | C34H42N6O6 | |
| Appearance | Solid | |
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1. Tibisay Guevara, et al. Sci Rep. 2019; 9: 4935.
2. Kataoka S, et al. FASEB J. 2014 Aug; 28(8):3564-78.
3. Kadowaki T, et al. Mol Pharmacol. 2004 Dec;66(6):1599-606.
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