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Chemical Structure : Ki20227
CAS No.: 623142-96-1
Catalog No.: PC-42568Not For Human Use, Lab Use Only.
Ki20227 is a potent, selective, orally active c-Fms inhibitor with IC50 of 2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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Ki20227 is a potent, selective, orally active c-Fms (CSF1R) inhibitor with IC50 of 2 nM.
Ki20227 weakly inhibits KDR, c-Kit, and PDGFRβ with IC50 of 12, 451, and 217 nM, respectively, no activty against Flt-3, c-Src, Fyn, EGFR, FGFR2, Met, Btk, PKA, and PKCα (IC50>1,000 nM).
Ki20227 inhibits the M-CSF-dependent cell growth, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.
| M.Wt | 480.5362 | |
| Formula | C24H24N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 7.2 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]- |
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1. Ohno H, et al. Mol Cancer Ther. 2006 Nov;5(11):2634-43.
2. Ohno H, et al. Eur J Immunol. 2008 Jan;38(1):283-91.
3. Uemura Y, et al. J Neuroimmunol. 2008 Mar;195(1-2):73-80.
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