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Chemical Structure : Kinetin riboside
Catalog No.: PC-42305Not For Human Use, Lab Use Only.
A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines.
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A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines; inhibits MiPaCa-2 cell proliferation with IC50 of 0.27 uM; induceds marked suppression of CCND2 transcription and rapidly suppresses cyclin D1 and D2 protein expression in primary myeloma cells and tumor lines, causing cell cycle arrest, tumor cell-selective apoptosis, and inhibition of myeloma growth in xenografted mice; also can activate PINK1 in cells independent of mitochondrial depolarization.
| M.Wt | 347.32598 | |
| Formula | C15H17N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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1. Osgerby L, et al. J Med Chem. 2017 Apr 27;60(8):3518-3524.
2. Tiedemann RE, et al. J Clin Invest. 2008 May;118(5):1750-64.
3. Hertz NT, et al. Cell. 2013 Aug 15;154(4):737-47.
4. Choi BH, et al. J Biol Chem. 2010 Mar 26;285(13):9770-9.
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