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Chemical Structure : Ku-DBi 245
Catalog No.: PC-20171Not For Human Use, Lab Use Only.
Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA.
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Ku-DBi 245 is a novel DNA-PK inhibitor with a unique mechanism of action, blocking the Ku 70/80 heterodimer interaction with DNA.
Ku-DBi 245 does not affect the cellular viability, but potentiates the cellular effects of bleomycin through inhibition of DNA-PKcs autophosphorylation events at S2056.
Ku-DBi 245 modulates the DNA damage response in response to DNA double-strand breaks.
Ku-DBi 245 impacts the ATM DDR signaling pathway in NSCLC cells, the phosphorylation of p53 is increased by bleomycin treatment and further increased by 245 combination treatment.
| M.Wt | 582.02 | |
| Formula | C30H24ClN7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mendoza-Munoz PL, et al. NAR Cancer. 2023 Feb 6;5(1):zcad003.
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