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Chemical Structure : L-732138
Catalog No.: PC-60341Not For Human Use, Lab Use Only.
A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.
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A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM; displays >1,000-fold selectvity over the human NK-2 and NK-3 receptors; inhibits substance P-induced inositol phosphate synthesis, abolishes vagally-induced plasma exudation and significantly inhibits exogenous substance enhancement indcued by LPS.
| M.Wt | 472.39 | |
| Formula | C22H18F6N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cascieri MA, et al. J Biol Chem. 1994 Mar 4;269(9):6587-91.
2. MacLeod AM, et al. J Med Chem. 1994 Apr 29;37(9):1269-74.
3. Pedersen KE, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):319-25.
4. Kuo HP, et al. Br J Pharmacol. 1998 Oct;125(4):711-6.
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