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Chemical Structure : L-779450
CAS No.: 303727-31-3
Catalog No.: PC-43208Not For Human Use, Lab Use Only.
L-779450 is a potent, ATP-competitive Raf kinase inhibitor with IC50 of 10 nM, displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $85 | In stock | |
| 25 mg | $225 | In stock | |
| 100 mg | $685 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
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L-779450 is a potent, ATP-competitive Raf kinase inhibitor with IC50 of 10 nM, displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively; suppresses DNA synthesis and induced apoptosis in hematopoietic FDC-P1 cells transformed to grow in response to either Raf-1 or A-Raf, L-779,450 is less effective on B-Raf- or MEK1-responsive cells, also suppresses DNA synthesis and induces apoptosis in Raf-responsive cells and the effects are more significant on Raf-responsive compared to cytokine-mediated growth.
| M.Wt | 347.7977 | |
| Formula | C20H14ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
Phenol, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]- |
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1. Shelton JG, et al. Leukemia. 2003 Sep;17(9):1765-82.
2. Takle AK, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6.
3. McKay MM, et al. Curr Biol. 2011 Apr 12;21(7):563-8.
4. Berger A, et al. J Invest Dermatol. 2014 Feb;134(2):430-440.
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