Chemical Structure : LA-CB1
CAS No.:
3032908-44-1
LA-CB1
Catalog No.: PC-24482Not For Human Use, Lab Use Only.
LA-CB1 is a novel Abemaciclib derivative that induces CDK4/6 degradation through the ubiquitin-proteasome pathway, exerts robust anti-proliferative effects across a wide spectrum of cancer cell lines (A498 cell, IC50=0.21 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LA-CB1 is a novel Abemaciclib derivative that induces CDK4/6 degradation through the ubiquitin-proteasome pathway, exerts robust anti-proliferative effects across a wide spectrum of cancer cell lines (A498 cell, IC50=0.21 uM).
LA-CB1 inhibits triple-negative breast cancer cell line MDA-MB-468 with IC50 of 0.45 uM.
LA-CB1 (0.25, 0.5, and 1 µM) inhibits the clonogenic growth and DNA synthesis in breast cancer cells.
LA-CB1 (1 uM) inhibits migration and invasion in MDA-MB-231 and MCF-7 cells by modulating EMT-related proteins.
LA-CB1 induces cell cycle arrest and promotes apoptosis in breast cancer cells, downregulates CDK4/6 and Cyclin D1, and promotes caspase-dependent apoptosis.
LA-CB1 (0.5 mg/kg, 1 mg/kg, and 2 mg/kg) inhibits tumor growth in an orthotopic 4T1 breast cancer model.
Physicochemical Properties
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M.Wt
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527.99
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Formula
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C28H23ClFN7O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((2-chloro-4-((4-(4-fluoro-1-isopropyl-2-methyl-1 H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)phenoxy)methyl)-3-cyanopyridine
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References
1. He J, et al. Sci Rep. 2025 Mar 4;15(1):7605.
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