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Chemical Structure : LAS101057
CAS No.: 925676-48-8
Catalog No.: PC-20638Not For Human Use, Lab Use Only.
LAS101057 (LAS 101057) is a potent, selective, and orally efficacious A2B adenosine receptor antagonist with Ki of 24 nM (human A2B).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LAS101057 (LAS 101057) is a potent, selective, and orally efficacious A2B adenosine receptor antagonist with Ki of 24 nM (human A2B).
LAS101057 is >400-fold selective in a diverse panel of more than 340 enzymes, receptors, channels, and transporters.
LAS101057 effects a concentration-dependent down-regulation of IL-6 production with a potency (67%) at 100 nM on NECA-induced IL-6 release in human primary dermal fibroblasts.
LAS101057 (10 mg/kg) is active in an ovalbumin (OVA)-sensitized mouse model after oral administration, reducing airway hyperresponsiveness to methacholine, Th2 cytokine production, and OVA-specific IgE levels.
| M.Wt | 335.34 | |
| Formula | C18H14FN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide |
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1. Paul Eastwood, et al. ACS Med Chem Lett. 2011 Mar 10; 2(3): 213–218.
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