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Chemical Structure : LAS191954
Catalog No.: PC-60447Not For Human Use, Lab Use Only.
LAS191954 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM.
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LAS191954 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM.
LAS191954 displays highest selectivity versus PI3Kα (IC50=8.2 uM) and the lowest versus PI3Kγ and PI3Kβ (IC50=72 and 94 nM respectively).
LAS191954 inhibits pAkt (Thr308) produced through PI3K with IC50 of 7.8 nM in THP-1 cells, inhibits IL2 production with an ID50 of 0.13 mg/kg in rat model of con A.
| M.Wt | 397.402 | |
| Formula | C20H15N9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Erra M, et al. ACS Med Chem Lett. 2016 Nov 30;8(1):118-123.
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