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Chemical Structure : LB-205
Catalog No.: PC-70352Not For Human Use, Lab Use Only.
LB-205 is a Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.
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LB-205 is a Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.
LB-205 significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA.
LB-205 up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax.
| M.Wt | 343.445 | |
| Formula | C18H21N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lu J, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5.
2. Lu J, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52.
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