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Chemical Structure : LDN-212854
CAS No.: 1432597-26-6
Catalog No.: PC-21393Not For Human Use, Lab Use Only.
LDN-212854 is an potent, ALK2-biased BMP type I receptor kinase (ACVR1) inhibitor that potently inhibits ALK2 (IC50=1.3 nM) and ALK1 (IC50=2.40 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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LDN-212854 is an potent, ALK2-biased BMP type I receptor kinase (ACVR1) inhibitor that potently inhibits ALK2 (IC50=1.3 nM) and ALK1 (IC50=2.40 nM).
LDN-212854 potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.
LDN-212854 suppresses HCC tumor progression through repression of ID1 in HCC xenografts model.
| M.Wt | 406.49 | |
| Formula | C25H22N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline |
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1. Mohedas AH, et al. ACS Chem Biol. 2013;8(6):1291-302.
2. Han Chen, et al. Mol Oncol. 2021 Aug;15(8):2203-2218.
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