Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : LEI-401
Catalog No.: PC-38219Not For Human Use, Lab Use Only.
LEI-401 (LEI 401) is a potent, selective, brain active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor with Ki of 2.7 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
LEI-401 (LEI 401) is a potent, selective, brain active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor with Ki of 2.7 nM.
LEI-401 does not inhibit enzymes involved in the biosynthesis and degradation of the other endocannabinoid 2-AG, DAGLα or DAGLβ, MAGL and α,β-hydrolase domain 6 (ABHD6).
LEI-401 reduced NAE levels in neuroblastoma cells and in the brain of freely moving mice, but not in NAPE-PLD KO cells and mice, respectively.
LEI-401 activated the hypothalamus-pituitary-adrenal (HPA) axis and impaired extinction of an aversive memory in mice, thereby mimicking the effects of cannabinoid CB1 receptor antagonism.
| M.Wt | 421.545 | |
| Formula | C24H31N5O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Mock ED, et al. Nat Chem Biol. 2020 Jun;16(6):667-675.
2. Mock ED, et al. J Med Chem. 2021 Jan 14;64(1):481-515.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
