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Chemical Structure : LG101506
Catalog No.: PC-20830Not For Human Use, Lab Use Only.
LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM.
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LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM.
LG101506 binds RXRalpha and activates RXR homo and heterodimers.
LG1506 is a potent insulin sensitizer that also enhances the insulin-sensitizing activities of rosiglitazone.
Administration of LG1506 reduces both body weight gain and food consumption and blocks the TZD-induced weight gain when coadministered with rosiglitazone.
LG1506 does not significantly suppress the thyroid hormone axis in rats, nor does it elevate triglycerides in Sprague Dawley rats.
LG1506 elevates high-density lipoprotein cholesterol in humanized apolipoprotein A-1-transgenic mice.
| M.Wt | 420.54 | |
| Formula | C25H34F2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Leibowitz MD, et al. Endocrinology. 2006 Feb;147(2):1044-53.
2. Gernert DL, et al. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3191-5.
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