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Chemical Structure : LGR6768
Catalog No.: PC-20315Not For Human Use, Lab Use Only.
LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs.
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LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs.
LGR6768 shows higher selectivity index than LDC4297 and samuraciclib.
LGR6768 shows antiproliferative and proapoptotic effect against a panel of 10 cell lines derived from haematological malignancies (IC50=0.4-4 uM).
LGR6768 downregulates the expression of transcription factors and apoptosis-related genes in the SEM and MOLM-13 cell lines.
| M.Wt | 458.63 | |
| Formula | C26H30N6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kovalová M, et al. Biomed Pharmacother. 2023 Mar 15;161:114492.
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