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Chemical Structure : LIMK-IN-14
Catalog No.: PC-70098Not For Human Use, Lab Use Only.
LIMK-IN-14 is a potent, selective LIMK inhibitor with IC50 of 0.9 nM and 0.5 nM and 1.2 nM for LIMK1 and LIMK2, respectively.
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LIMK-IN-14 is a potent, selective LIMK inhibitor with IC50 of 0.9 nM and 0.5 nM and 1.2 nM for LIMK1 and LIMK2, respectively.
LIMK-IN-14 displays >100-fold selectivity for LIMK2 against ROCK1 and >900-fold selectivity against ROCK2.
LIMK-IN-14 reduces intraocular pressure to baseline levels in a steroid induced mouse model of ocular hypertension (topical dosing).
| M.Wt | 437.504 | |
| Formula | C22H27N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Harrison BA, et al. J Med Chem. 2009 Nov 12;52(21):6515-8.
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